NFL PrizePicks Predictions Week 16: 5 Must-Play Picks Led by Baker Mayfield

NFL PrizePicks

Welcome to the thrilling world of PrizePicks, where we dive into the player offers on the board for Week 16 of the NFL season. Our STB NFL Prizepicks predictions are fueled by projections, trends, and the ever-evolving betting data.

PrizePicks, the most popular DFS Pick’em site, lays out player stat projections like a delectable buffet for us to devour this holiday weekend. We get to construct a ticket for our user-created entries, carefully selecting players based on whether we believe they will surpass or fall short of the statistical line offered. With a vast array of options featuring hundreds of players, we only need to make a minimum of two picks to create a winning entry.

If you do not have the PrizePicks app, use our PrizePicks referral code for a 100% deposit match of up to $100. Other apps like Prizepicks are also available.

Betr Picks

💰 $250 NO SWEATR' ENTRY FOR NEW PLAYERS



🔥 Use Promo Code STB500 when signing up with Betr Picks

  • Betr Picks is a pick’em style DFS app
  • Users build lineups that consist of 2 or more players
  • Payouts can be up to 300x your entry fee!


Must 21+ years of age and located within a state that Betr Picks operates. T&C's apply. Concerned about your play? Call the NCPAG at 1800-522-4700

Let’s dive into our Prizepicks NFL Week 16 predictions, as we scoured the board to decipher the intricacies of player usage, game flow, odds, and, of course, our trusty trends.

PrizePicks Top Plays for NFL Week 16

  • Raheem Mostert MORE than 57.5 rushing yards
  • Baker Mayfield MORE than 229.5 passing yards
  • Derrick Henry MORE than 65.5 rushing yards
  • Mike Evans MORE than 69.5 receiving yards
  • David Njoku MORE than 49.5 receiving yards

Derrick Henry: Will he surpass 65.5 rushing yards or fall short?

Derrick Henry’s recent performance in terms of yardage has been rather lackluster, with only two out of his last six games yielding impressive results. However, the Tennessee Titans find themselves lacking a quarterback, placing a significant burden on Henry’s shoulders. Over the past four games, Henry has been handed the ball 16, 17, 21, and 18 times, showcasing his importance to the team. With an impressive projected total of 80.5 rushing yards, well above the PrizePicks prediction of 65.5, it’s evident that Henry is poised to make a significant impact.

The Seattle Seahawks can’t be underestimated, as they possess a moderately formidable defense. Nevertheless, they have allowed an average of 127.3 yards, which is the fourth-most yards allowed in the league. Considering the sheer volume of carries that Henry is likely to receive, this matchup against the Seahawks can’t be ignored. PICK: MORE THAN 65.5 YARDS

David Njoku: Will he exceed 49.5 receiving yards?

Without a doubt, one of the top picks for Week 16 is David Njoku. In five of his last six games, Njoku has surpassed this receiving yards total, averaging an impressive 64 yards per game during that span. Moreover, he has emerged as a favored target for Joe Flacco, with an average of over nine targets per game across the three games Flacco has started. Njoku has also seen an impressive total of 22 targets in the previous two games.

To add to the allure, the matchup against the Houston Texans couldn’t be more enticing. Throughout the season, the Texans have allowed the fourth-most receiving yards to tight ends. Furthermore, they have permitted an average of 60 receiving yards per game to the position.

PICK: MORE THAN 49.5 YARDS

Raheem Mostert: Can he surpass 57.5 rushing yards?

Raheem Mostert has proven his ability to exceed this rushing yards total in four out of his last six games, accomplishing this feat in a total of eight games this season. With an average of nearly 18 carries per game over the past five weeks, the Miami Dolphins are heavily involving Mostert in their ground game.

Over the last four weeks, the Cowboys have given up a staggering 481 rushing yards to opposing running backs, ranking them fourth-worst in the league. Additionally, we have witnessed two running backs surpassing the 57.5 rushing yards total in the past three weeks as well. Notably, James Cook wreaked havoc on the Cowboys’ defense last week, amassing an astounding 179 rushing yards. PICK: MORE THAN 57.5 YARDS

Mike Evans: Will he exceed 63.5 receiving yards?

Mike Evans has proven his capacity to surpass this receiving yards total in three out of his last four games. With an average of over nine targets per game across his previous six games. The Tampa Bay Buccaneers face a favorable matchup as the Jacksonville Jaguars have surrendered the ninth-most receiving yards to wide receivers, averaging nearly 164 receiving yards per game. Furthermore, while the Jaguars excel at limiting rushing yards to the opposing running backs, this suggests that the Buccaneers will rely heavily on the passing game to move the ball effectively. PICK: MORE THAN 63.5 YARDS

Baker Mayfield: Can he surpass 229.5 passing yards?

Pairing Baker Mayfield with Mike Evans in this game seems like a logical move. As previously mentioned, the Jaguars’ run defense has proven to be formidable; however, their pass defense leaves much to be desired. They have relinquished an average of just over 271 passing yards per game to opposing quarterbacks, ranking them as the fifth-worst in the league. Mayfield has gone over this passing yards total in eight out of the 14 games he has played this season.

Moreover, his recent display of passing prowess, with 381 yards against the Green Bay Packers in Week 15, serves as a testament to his current form. PICK: MORE THAN 229.5 YARDS

Betr Picks

💰 $250 NO SWEATR' ENTRY FOR NEW PLAYERS



🔥 Use Promo Code STB500 when signing up with Betr Picks

  • Betr Picks is a pick’em style DFS app
  • Users build lineups that consist of 2 or more players
  • Payouts can be up to 300x your entry fee!


Must 21+ years of age and located within a state that Betr Picks operates. T&C's apply. Concerned about your play? Call the NCPAG at 1800-522-4700
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